About
TI-Toolbox is an open-source platform for temporal interference (TI) brain-stimulation research. It helps researchers explore how electrode placement and stimulation settings shape electric fields in the brain, bringing study planning, simulation, and analysis into one workflow.
Started as a side project in 2024, the toolbox supports both researchers new to TI modeling and experienced users working with larger studies. You can explore stimulation using standard head models or personalize a study with a participant’s MRI.
From a research question to results
- Prepare your study — organize imaging data and build head models that represent the anatomy you want to study.
- Explore stimulation — simulate electrode arrangements and visualize the resulting electric fields.
- Find promising settings — search for electrode placements and currents that focus stimulation on your region of interest.
- Compare and communicate — analyze target regions, compare results across participants, and create figures and reports.
Use the desktop interface to work through a study, or build on the same tools in scripts and notebooks when you need a custom workflow.
Built for research
TI-Toolbox brings related modeling tasks together so you can spend more time on your research questions. Organized projects, reusable settings, and saved results help you revisit analyses and share your work with collaborators.
The project is developed openly on GitHub, with contributions from the research community. Feedback, questions, and ideas help shape its development.
Get started · Explore the user guide · Report an issue
Contributors
Ido Haber
Lead Developer & Project Founder
PhD Research Assistant and software developer specializing in computational neurostimulation. Developed the idea and architecture for the TI-Toolbox.
- Project direction and software development
- Research workflows, user experience, and documentation
Larissa Albantakis
Core Contributor
Larissa Albantakis, PhD is a computational neuroscientist and Assistant Professor of Computational Psychiatry at University of Wisconsin - Madison.
- Methods for modeling stimulation with multiple electrode pairs
- Electrode search and visualization of candidate arrangements
Past contributors
Acknowledgments
TI-Toolbox builds on the work of the open-source neuroimaging community, including SimNIBS, FreeSurfer, FastSurfer, FSL, QSIPrep, and QSIRecon. We thank their developers, the BIDS community, and the contributors to the many scientific and visualization tools that support this work.
If you use TI-Toolbox in a publication, please cite the software and its associated paper, along with the underlying tools used in your study.